Akt/PKB, a serine/threonine kinase member of the AGC family of proteins, is involved in the regulation of a plethora of cellular processes triggered by a wide diversity of extracellular signals and is thus considered a key signalling molecule in higher eukaryotes. Deregulation of Akt signalling is associated with a variety of human diseases, revealing Akt-dependent pathways as an attractive target for therapeutic intervention. Since its discovery in the early 1990s, a large body of work has focused on Akt phosphorylation of two residues, Thr308 and Ser473, and modification of these two sites has been established as being equivalent to Akt activation. More recently, Akt has been identified as a substrate for many different post-translational modifications, including not only phosphorylation of other residues, but also acetylation, glycosylation, oxidation, ubiquitination and SUMOylation. These modifications could provide additional regulatory steps for fine-tuning Akt function, Akt trafficking within the cell and/or for determining the substrate specificity of this signalling molecule. In the present review, we provide an overview of these different post-translational modifications identified for Akt, focusing on their consequences for this kinase activity.
Bozulic L, Hemmings BA. Bozulic L, et al. Curr Opin Cell Biol. 2009 Apr;21(2):256-61. doi: 10.1016/j.ceb.2009.02.002. Epub 2009 Mar 19. Curr Opin Cell Biol. 2009. PMID: 19303758 Review.
Wei Y, Zhou J, Yu H, Jin X. Wei Y, et al. Biosci Biotechnol Biochem. 2019 Mar;83(3):429-435. doi: 10.1080/09168451.2018.1549974. Epub 2018 Nov 29. Biosci Biotechnol Biochem. 2019. PMID: 30488766
Hoshino Y, Sato E. Hoshino Y, et al. Dev Biol. 2008 Feb 1;314(1):215-23. doi: 10.1016/j.ydbio.2007.12.005. Epub 2007 Dec 15. Dev Biol. 2008. PMID: 18177853
Cecconi S, Rossi G, Deldar H, Cellini V, Patacchiola F, Carta G, Macchiarelli G, Canipari R. Cecconi S, et al. Reprod Fertil Dev. 2014;26(4):562-9. doi: 10.1071/RD13010. Reprod Fertil Dev. 2014. PMID: 23622715
Kandel ES, Hay N. Kandel ES, et al. Exp Cell Res. 1999 Nov 25;253(1):210-29. doi: 10.1006/excr.1999.4690. Exp Cell Res. 1999. PMID: 10579924 Review.
Keshri PK, Singh SP. Keshri PK, et al. Arch Toxicol. 2024 Aug 13. doi: 10.1007/s00204-024-03829-9. Online ahead of print. Arch Toxicol. 2024. PMID: 39136731 Review.
Jiang Q, Xiao J, Hsieh YC, Kumar NL, Han L, Zou Y, Li H. Jiang Q, et al. Biomedicines. 2024 Jul 19;12(7):1610. doi: 10.3390/biomedicines12071610. Biomedicines. 2024. PMID: 39062182 Free PMC article. Review.
Pu Y, Yang J, Pan Q, Li C, Wang L, Xie X, Chen X, Xiao F, Chen G. Pu Y, et al. J Biol Chem. 2024 Aug;300(8):107530. doi: 10.1016/j.jbc.2024.107530. Epub 2024 Jul 4. J Biol Chem. 2024. PMID: 38971310 Free PMC article.
Mei C, Chen T, Huang X, Xiong C, Chen S, Li Y. Mei C, et al. Exp Ther Med. 2024 Mar 8;27(5):190. doi: 10.3892/etm.2024.12478. eCollection 2024 May. Exp Ther Med. 2024. PMID: 38533431 Free PMC article. Review.
Aghaei-Zarch SM. Aghaei-Zarch SM. Noncoding RNA Res. 2024 Jan 14;9(2):486-507. doi: 10.1016/j.ncrna.2024.01.005. eCollection 2024 Jun. Noncoding RNA Res. 2024. PMID: 38511053 Free PMC article. Review.